Trihexane
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Generic Name: trihexyphenidyl
(try hex ee FEH nih dill)
What is Trihexane?
Trihexane alters unusual nerve impulses and relaxes stiff muscles.
Trihexane is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.
Trihexane may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Trihexane?
Use caution when driving, operating machinery, or performing other hazardous activities. Trihexane may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Trihexane.
Avoid becoming overheated. Trihexane may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise.
What should I discuss with my healthcare provider before taking Trihexane?
Do not use Trihexane without first talking to your doctor if you have
Before taking this medication, tell your doctor if you have
You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
It is not known whether Trihexane will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.
It is not known whether Trihexane passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
How should I take Trihexane?
Take Trihexane exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Trihexane may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset.
To ensure that you get a correct dose, measure the liquid form of Trihexane with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Store Trihexane at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of a Trihexane overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures.
What should I avoid while taking Trihexane?
Use caution when driving, operating machinery, or performing other hazardous activities. Trihexane may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Trihexane.
Avoid becoming overheated. Trihexane may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.
What are the possible side effects of Trihexane?
If you experience any of the following serious side effects, stop taking Trihexane and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
- fever
- fast or irregular heartbeats
- anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness
- seizures
- eye pain; or
- a rash.
Other, less serious side effects may be more likely to occur. Continue to take Trihexane and talk to your doctor if you experience
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Trihexane?
Before taking this medication, tell your doctor if you are taking any of the following medicines:
- a tricyclic antidepressant (used to treat depression, pain, or obsessive-compulsive disorder) such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), amoxapine (Asendin), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), or protriptyline (Vivactil)
- a phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others
- thiothixene (Navane) or chlorprothixene (Taractan)
- an antihistamine such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist), and others (antihistamines are often found in prescription and over-the-counter cold, allergy, and sleep medicines)
- quinidine (Quinora, Quinaglute, Quinidex, Cardioquin)
- amantadine (Symmetrel)
- digoxin (Lanoxin, Lanoxicaps); or
- haloperidol (Haldol).
You may not be able to take Trihexane or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with Trihexane. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Where can I get more information?
Your pharmacist has more information about Trihexane written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2009 Cerner Multum, Inc. Version: 4.01. Revision date: 07/02/2009.
