Lonox



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Generic Name: atropine and diphenoxylate
(A troe peen and DYE fen OX i late)

What is Lonox?

Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines.

Diphenoxylate is an antidiarrheal medication.

The combination of Lonox is used to treat diarrhea.

Lonox may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Lonox?

If you are giving this medication to a child, pay close attention to the dose. An Lonox overdose is more likely to occur in a child, and can cause breathing problems or result in death or permanent brain damage.

Use only the liquid form of this medicine in a child younger than 13 years old. Do not give Lonox tablets to a child under 13.

Drink extra water while you are taking this medication to keep from getting dehydrated.

It may take up to 48 hours of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 10 days of treatment.

What should I discuss with my healthcare provider before taking Lonox?

Do not use this medication if you are allergic to atropine or diphenoxylate, or if you have:

  • jaundice (yellowing of your skin or eyes caused by a liver disorder)
  • diarrhea that is caused by bacteria; or
  • diarrhea caused by taking an antibiotic.

Before taking Lonox, tell your doctor if you are allergic to any drugs, or if you have:

  • blocked intestines
  • an intestinal disorder such as ulcerative colitis or Crohn's disease
  • liver disease
  • kidney disease
  • heart disease, heart rhythm problems, or high blood pressure
  • glaucoma
  • Down's syndrome
  • a thyroid disorder
  • problems with urination
  • an enlarged prostate
  • asthma or other lung problems; or
  • if you are dehydrated;

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Lonox.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Lonox may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to a child younger than 2 years old.

How should I take Lonox?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you are giving this medication to a child, pay close attention to the dose. An Lonox overdose is more likely to occur in a child, and can cause breathing problems or result in death or permanent brain damage.

Use only the liquid form of this medicine in a child younger than 13 years old. Do not give Lonox tablets to a child under 13.

Take the medicine with a full glass of water. Drink extra water while you are taking Lonox to keep from getting dehydrated.

It may take up to 48 hours of using the medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 10 days of treatment.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Store Lonox at room temperature away from moisture and heat.

Keep the medication where a child cannot reach it. An overdose of Lonox can be fatal to a child.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine, or if a child has accidentally swallowed it. An overdose of Lonox can cause breathing problems and may result in death or permanent brain damage.

Early overdose symptoms may include dry skin, dry mouth or nose, blurred vision, restless feeling, feeling too warm or cold, tingly feeling, and a fast heart rate.

Progressing symptoms of an Lonox overdose include weakness, pinpoint pupils in the eyes, weak or shallow breathing, fainting, or coma. Report any early overdose symptoms to your doctor as soon as possible.

What should I avoid while taking Lonox?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol while you are taking this medication. Alcohol can increase some of the side effects of Lonox.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by Lonox. Tell your doctor if you regularly use any of these other medicines.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink.

What are the possible side effects of Lonox?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • stomach pain or bloating
  • ongoing or worsening diarrhea
  • diarrhea that is watery or bloody
  • numbness in your hands or feet
  • depressed mood
  • confusion, unusual thoughts or behavior
  • fast heart rate; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, dizziness, headache
  • tired or restless feeling
  • nausea, vomiting, upset stomach, loss of appetite; or
  • skin rash, or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lonox?

Before taking Lonox, tell your doctor if you are using any of the following drugs:

  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or
  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with Lonox. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about Lonox.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.