Keep Alert



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Accepted at over 60,000 pharmacies nationwide

Generic Name: caffeine citrate (oral)
(KAF een SIT rate)

What is Keep Alert?

Keep Alert is a central nervous system stimulant. It also has effects on the lungs and metabolism.

Keep Alert is used to treat breathing problems in premature infants.

Keep Alert may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Keep Alert?

Keep Alert should not be given to a child who has had an allergic reaction to it in the past.

Before using Keep Alert, tell the doctor if your child is allergic to any drugs, or has a seizure disorder, heart disease, kidney disease, liver disease, or high or low blood sugar.

Do not use the medication for longer than 12 days without the advice of your child's doctor.

Each bottle of Keep Alert is for one use only, even if your child does not use the entire bottle for a single dose. Throw away any medication left over in the bottle after measuring your child's dose.

Call your doctor if the child's breathing symptoms do not improve after using Keep Alert.

To be sure Keep Alert is helping your child's condition, the child's blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What should I discuss with my health care provider before taking Keep Alert?

Keep Alert should not be given to a child who has had an allergic reaction to it in the past.

Before using Keep Alert, tell the doctor if your child is allergic to any drugs, or if the child has:

  • seizures
  • heart disease
  • kidney disease;
  • liver disease; or
  • high or low blood sugar.

If your child has any of these conditions, he or she may need a dose adjustment or special tests to safely take this medication.

This medication may be harmful to an unborn baby and should not be taken by a woman who is pregnant. Keep Alert should also not be taken by a woman who is breast-feeding a baby.

How should I take Keep Alert?

Use this medication exactly as it was prescribed for your child. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on the prescription label.

Keep Alert is for short-term use only. Do not use the medication for longer than 12 days without the advice of your child's doctor.

Measure Keep Alert with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Each bottle of Keep Alert is for one use only, even if your child does not use the entire bottle for a single dose. Throw away any medication left over in the bottle after measuring your child's dose.

Do not use the medication if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.

Call your doctor if the child's breathing symptoms do not improve after using Keep Alert.

To be sure Keep Alert is helping your child's condition, the child's blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Store the medication at room temperature away from heat and moisture. Do not open a bottle of Keep Alert until you are ready to give the dose. This medication contains no preservatives.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your child's next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have given your child too much of this medicine.

Overdose symptoms may include loss of appetite, sleep problems, fussiness, or excessive crying.

What should I avoid while taking Keep Alert?

Avoid giving the child food or drinks that contain caffeine, such as cola or chocolate milk.

What are the possible side effects of Keep Alert?

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Keep Alert and call your doctor at once if your child has any of these serious side effects:

  • stomach pain, tenderness, bloating,
  • constipation or diarrhea
  • green-colored vomit
  • blood in the stools
  • unusual weakness
  • seizure (convulsions)
  • twitching or uncontrolled muscle movements; or
  • fever, fast or slow heart rate.

Less serious side effects may include sleep problems, loss of appetite, fussiness, or excessive crying.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Keep Alert?

Before using Keep Alert, tell your child's doctor if the child is using any of the following drugs:

  • cimetidine (Tagamet)
  • ketoconazole (Nizoral)
  • phenobarbital (Luminal, Solfoton);
  • phenytoin (Dilantin); or
  • theophylline (Elixophyllin, Slo-Bid, Theo-Dur, Uniphyl, and others).

There may be other drugs not listed that can affect Keep Alert. Tell your doctor about all the prescription and over-the-counter medications you are giving to your child. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your child's doctor.

Where can I get more information?

Your pharmacist can provide more information about Keep Alert.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.