Doxil



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Generic Name: doxorubicin liposomal
(DOZ oh ROO bi sin LYE poe SOE mal)

What is Doxil?

Doxil is a cancer (antineoplastic) medication. Doxorubicin liposomal interferes with the growth of cancer cells and slows their growth and spread in the body.

Doxil is used to treat metastatic ovarian cancer and AIDS-related Kaposi's sarcoma.

Doxil may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Doxil?

Doxil should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of Doxil including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); severe heart damage with prolonged use; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with doxorubicin liposomal.

Who should not use Doxil?

Do not use Doxil without first talking to your doctor if you have

  • kidney disease
  • liver disease
  • heart disease
  • poor bone marrow function
  • received radiation therapy that encompassed the heart; or
  • previously received treatment with doxorubicin (Adriamycin, Rubex), Doxil (Doxil), daunorubicin (Cerubidine), daunorubicin liposomal (Daunoxome), idarubicin (Idamycin), or mitoxantrone (Novantrone).
  • The use of Doxil may be dangerous if you have any of the conditions listed above.

    Doxil is in the FDA pregnancy category D. This means that doxorubicin liposomal is known to be harmful to an unborn baby. Do not use doxorubicin liposomal without first talking to your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during, and for several months following, treatment with doxorubicin liposomal if necessary.

    Because of the potential for serious side effects in a nursing infant, breast-feeding should be avoided during treatment with Doxil.

    How should I use Doxil?

    Doxil should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

    Your doctor will determine the correct amount and frequency of treatment with Doxil depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

    Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with Doxil to monitor progress and side effects.

    Skin accidentally exposed to Doxil should be rinsed thoroughly with soap and warm water.

    Your healthcare provider will store Doxil as directed by the manufacturer. If you are storing doxorubicin liposomal at home, follow the directions provided by your healthcare provider.

    What happens if I miss a dose?

    Contact your doctor if you miss a dose of Doxil.

    What happens if I overdose?

    If for any reason an overdose of Doxil is suspected, seek emergency medical attention or contact your healthcare provider immediately.

    Symptoms of a Doxil overdose tend to be similar to side effects caused by the medication, although often more severe.

    What should I avoid while using Doxil?

    Doxil can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with doxorubicin liposomal. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

    Skin accidentally exposed to Doxil should be rinsed thoroughly with soap and warm water.

    What are the possible side effects of Doxil?

    If you experience all of the following serious side effects from Doxil, contact your doctor immediately:

    • an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
    • decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection)
    • congestive heart failure (difficulty breathing, fluid retention, chest pain)
    • irregular heartbeats
    • tissue or vein reactions near the site of administration
    • liver damage (abdominal pain, yellowing of the skin or eyes)
    • severe nausea, vomiting, diarrhea, and loss of appetite
    • inflamation and sores inside the mouth, throat, or intestines
    • fever, chills, or other signs of infection
    • tingling, burning, redness, flaking, bothersome swelling, small blisters, or small sores on the palms of the hands or soles of the feet
    • numbness, tingling, or difficult movement of a body part
    • seizures; or
    • increased levels of uric acid in the body (joint pain and stiffness).

    Other, less serious side effects may be more likely to occur. Continue taking Doxil and talk to your doctor if you experience:

    • facial flushing during administration
    • headache
    • temporary hair loss; or
    • red colored urine shortly after receiving a dose (may continue for 1 or 2 days).

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    What other drugs will affect Doxil?

    Do not use Doxil without first talking to your doctor if you have had previous treatment with doxorubicin (Adriamycin, Rubex), doxorubicin liposomal (Doxil), daunorubicin (Cerubidine), daunorubicin liposomal (Daunoxome), idarubicin (Idamycin), or mitoxantrone (Novantrone). Because there is a maximum amount of these medications that should be administered to an individual, you may not be able to use doxorubicin.

    Do not receive "live" vaccines during treatment with Doxil. Administration of a live vaccine may be dangerous during treatment with doxorubicin liposomal.

    Drugs other than those listed here may also interact with Doxil. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with doxorubicin liposomal.

    Where can I get more information?

    Your healthcare provider may have additional information about Doxil that you may read.


    Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

    Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.