Autoplex T
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Generic Name: anti-inhibitor coagulant complex (injectable)
(an TEE in HIH bih tor coe AG you lant COM plex)
What is Autoplex T?
Autoplex T is made up of proteins normally present in the blood that allow the blood to clot.
Autoplex T is used to treat or prevent bleeding in people with hemophilia and Factor VIII inhibitors.
Autoplex T may also be used for purposes other than those listed here.
What is the most important information I should know about Autoplex T?
Autoplex T is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although anti-inhibitor coagulant complex is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using anti-inhibitor coagulant complex.
Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from Autoplex T. Parovovirus B19 may more seriously affect pregnant women and those with poor immune systems. Symptoms of parovovirus B19 infection include fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain. Symptoms of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark-colored urine and yellowing of the skin or whites of the eyes may also occur. Contact your doctor if you develop any of these symptoms after treatment with anti-inhibitor coagulant complex.
Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.
Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.
What should I discuss with my healthcare provider before using Autoplex T?
Do not use Autoplex T without first talking to your doctor if you have
You may not be able to use Autoplex T or you may require a dosage adjustment or special monitoring during treatment.
Autoplex T is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use anti-inhibitor coagulant complex without first talking to your doctor if you are pregnant.
It is not known whether Autoplex T could be harmful to a nursing baby. Do not use anti-inhibitor coagulant complex without first talking to your doctor if you are breast-feeding a baby.
How should I use Autoplex T?
Autoplex T will be administered by intravenous (into a vein) injection by a healthcare provider.
Your doctor may want you to have blood tests or other medical evaluations during treatment with Autoplex T to monitor progress and side effects.
Carry or wear identification that will alert others that you have hemophilia or another blood clotting disorder in the case of an emergency.
Your healthcare provider will store Autoplex T as directed by the manufacturer.
If you are using Autoplex T at home, your doctor or healthcare provider will give you detailed instructions on how to administer and store the medication.
What happens if I miss a dose?
Contact your doctor if a dose of Autoplex T is missed.
What happens if I overdose?
Seek emergency medical attention if an overdose of Autoplex T is suspected.
What should I avoid while using Autoplex T?
Tell your doctor and dentist that you have hemophilia or another blood clotting disorder before having surgery or other invasive procedures.
What are the possible side effects of Autoplex T?
Autoplex T is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although anti-inhibitor coagulant complex is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using anti-inhibitor coagulant complex.
Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from Autoplex T. Parovovirus B19 may more seriously affect pregnant women and those with poor immune systems. Symptoms of parovovirus B19 infection include fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain. Symptoms of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark-colored urine and yellowing of the skin or whites of the eyes may also occur. Contact your doctor if you develop any of these symptoms after treatment with anti-inhibitor coagulant complex.
If you experience any of the following serious side effects, contact your healthcare provider immediately or seek emergency medical attention:
- an allergic reaction (shortness of breath; wheezing; tightness of the chest; closing of the throat; hives; swelling of the lips, face, or tongue; hives or rash; dizziness or fainting)
- changes in pulse rate or blood pressure
- difficulty breathing, chest pain, or cough; or
- pain, redness, or swelling at the injection site.
Other, less serious side effects may be more likely to occur. Continue to use Autoplex T and talk to your doctor if you experience
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Autoplex T?
Other drugs that affect bleeding or blood-clotting processes can interact with Autoplex T resulting in dangerous side effects and/or altered effectiveness. Do not take any other prescription or over-the-counter medicines, including herbal products, without first talking to your doctor during treatment with anti-inhibitor coagulant complex.
Where can I get more information?
Your pharmacist has additional information about Autoplex T written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2009 Cerner Multum, Inc. Version: 1.05. Revision Date: 4/12/2009.
